Advanced pulmonary drug delivery formulations for the treatment of cystic fibrosis
Akshay Parihar, Bhupendra G. Prajapati, Himanshu Paliwal, Maheka Shukla, Dignesh Khunt, Sumedh Bahadure, Sathish Dyawanapelly, Vijayabhaskarreddy Junnuthula
Abstract
Cystic fibrosis (CF), a fatal genetic condition, causes thick, sticky mucus. It also causes pancreatic dysfunction, bacterial infection, and increased salt loss. Currently available treatments can improve the patient's quality of life. Drug delivery aided by nanotechnology has been explored to alter the pharmacokinetics and toxicity of drugs. In this short review, we aim to summarize various conventional formulations and highlight advanced formulations delivered via the pulmonary route for the treatment of CF. There is considerable interest in advanced drug delivery formulations addressing the various challenges posed by CF. Despite their potential to be translated for clinical use, we anticipate that a significant amount of effort may still be required for translation to the clinic.