Establishing immune scoring model based on combination of the number, function, and phenotype of lymphocytes
Guoxing Tang, Yuan Xu, Ying Luo, Qun Lin, Zhishui Chen, Xue Xing, Huijuan Song, Shiji Wu, Hongyan Hou, Jing Yu, Liyan Mao, Weiyong Liu, Feng Wang, Sun Ziyong
Abstract
BACKGROUND: Quantitatively assessing host immunity remains a challenge in clinical practice. RESULTS: T cell number, NK cell number × function) from the results of lymphocyte number, function, and phenotype. This immune scoring model showed sensitivities of 70% and 71.4% in determining hyper-immune and hypo-immune status, respectively. CONCLUSIONS: An immune scoring model based on combination of lymphocyte number, function, and phenotype shows potential value in quantitatively assessing host immunity. METHODS: T cells and NK cells were simultaneously determined.
Topics & Concepts
CD28Immune systemCD8Cytotoxic T cellImmunologyT cellPhenotypeBiologyNaive T cellIn vitroGeneticsT-cell receptorGeneImmune Cell Function and InteractionT-cell and B-cell ImmunologyReproductive System and Pregnancy