NOX4 is a potential therapeutic target in septic acute kidney injury by inhibiting mitochondrial dysfunction and inflammation
Jiameng Li, Liya Wang, Bo Wang, Zhuyun Zhang, Luojia Jiang, Zheng Qin, Yuliang Zhao, Baihai Su
Abstract
Collectively, genetic or pharmacological inhibition of NOX4 protects from S-AKI by reducing generation of ROS and activation of NF-κB signal, which suppress mitochondrial dysfunction, inflammation together with apoptosis. NOX4 may act as a novel target for the S-AKI therapy.
Topics & Concepts
InflammationAcute kidney injuryMedicinePharmacologyInternal medicineAcute Kidney Injury ResearchSepsis Diagnosis and TreatmentTraumatic Brain Injury and Neurovascular Disturbances