AZD4547 targets the FGFR/Akt/SOX2 axis to overcome paclitaxel resistance in head and neck cancer
Abdulmelik Aytatlı, Neslisah Barlak, Fatma Şanli, Hasan Onur Çağlar, Betül Gündoğdu, Arzu Tatar, Michael Ittmann, Ömer Faruk Karataş
Topics & Concepts
SOX2Fibroblast growth factor receptorCancer researchProtein kinase BPI3K/AKT/mTOR pathwayHead and neck squamous-cell carcinomaMedicineCancerCancer cellInternal medicineHead and neck cancerBiologyFibroblast growth factorReceptorSignal transductionCell biologyTranscription factorBiochemistryGeneFibroblast Growth Factor ResearchProteoglycans and glycosaminoglycans researchCancer-related Molecular Pathways