Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
Ke Cong, Min Peng, Arne Nedergaard Kousholt, Wei Ting C. Lee, Silviana Lee, Sumeet U. Nayak, John J. Krais, Pamela S. VanderVere-Carozza, Katherine S. Pawelczak, Jennifer A. Calvo, Nicholas J. Panzarino, John J. Turchi, Neil Johnson, Jos Jonkers, Eli Rothenberg, Sharon B. Cantor
Topics & Concepts
Synthetic lethalityBiologyPARP1Poly ADP ribose polymeraseHomologous recombinationPolymerasePARP inhibitorDNA repairRAD51DNA damageXRCC1Cancer researchCell biologyGeneticsMolecular biologyDNAGenotypeGeneSingle-nucleotide polymorphismPARP inhibition in cancer therapyDNA Repair MechanismsCRISPR and Genetic Engineering