Listeria monocytogenes MenI Encodes a DHNA-CoA Thioesterase Necessary for Menaquinone Biosynthesis, Cytosolic Survival, and Virulence
Hans B. Smith, Tin Lok Li, Man Kit Liao, Grischa Y. Chen, Zhihong Guo, John‐Demian Sauer
Abstract
requires the production of 1,4-dihydroxy-2-naphthoate (DHNA). Taken together, these data implicate LMRG_02730 (renamed MenI) as a DHNA-CoA thioesterase and suggest that while DHNA, or an unknown downstream product of DHNA, protects the bacteria from killing in the macrophage cytosol, DHNA-CoA is necessary for intracellular bacterial replication.
Topics & Concepts
BiologyVirulenceBiochemistryMicrobiologyThioesteraseEscherichia coliCytosolBiosynthesisEnzymeGeneListeria monocytogenes in Food SafetyVitamin C and Antioxidants ResearchMicrobial Metabolism and Applications