<i>In vivo</i> metal-catalyzed SeCT therapy by a proapoptotic peptide
Peni Ahmadi, Kyohei Muguruma, Tsung‐Che Chang, Satoru Tamura, Kazuki Tsubokura, Yasuko Egawa, Takehiro Suzuki, Naoshi Dohmae, Yoichi Nakao, Katsunori Tanaka
Abstract
The combination of a proapoptotic peptide with covalent tagging and a carrier-Ru-complex inhibited tumor growth in mice after a single injection.
Topics & Concepts
In vivoApoptosisCatalysisPeptideChemistryAlkylationCancer researchIn vitroCellCancer therapyCombinatorial chemistryStereochemistryCancerBiochemistryBiologyMedicineInternal medicineGeneticsClick Chemistry and ApplicationsAdvanced biosensing and bioanalysis techniquesPeptidase Inhibition and Analysis