Restoration of CPT1A-mediated fatty acid oxidation in mesothelial cells protects against peritoneal fibrosis
Wenyan Su, Zuoyu Hu, Xiaohong Zhong, Ansheng Cong, Ying Zhang, Zhanmei Zhou, Jianyi Li, Cailing Su, Yujie Huang, Wei Cao
Abstract
A defective FAO is responsible for the profibrotic response of mesothelial cells and thus the peritoneal fibrogenesis. This aberrant metabolic state could be improved by modulating CPT1A in mesothelial cells, suggesting FAO enhancement in mesothelial cells is a potential treatment of peritoneal fibrosis.
Topics & Concepts
Mesothelial CellBiologyFibrosisPeritoneumCell cultureMolecular biologyEndocrinologyInternal medicinePathologyMedicineGeneticsAnatomyDialysis and Renal Disease ManagementParathyroid Disorders and TreatmentsPancreatitis Pathology and Treatment