The USP10/13 inhibitor, spautin-1, attenuates the progression of glioblastoma by independently regulating RAF-ERK mediated glycolysis and SKP2.
Swathi V. Kona, Shasi V. Kalivendi
Topics & Concepts
MAPK/ERK pathwayCancer researchGlycolysisGene knockdownGlioblastomaTumor progressionBiologyAnaerobic glycolysisGliomaKinaseCell biologyCancerEndocrinologyApoptosisBiochemistryMetabolismGeneticsUbiquitin and proteasome pathwaysMicrotubule and mitosis dynamicsGlioma Diagnosis and Treatment