Amyloid β-but not Tau-induced neurotoxicity is suppressed by Manuka honey<i>via</i>HSP-16.2 and SKN-1/Nrf2 pathways in an<i>in vivo</i>model of Alzheimer's disease
María D. Navarro‐Hortal, José M. Romero‐Márquez, Pedro Muñoz-Ollero, Victoria Jiménez-Trigo, Adelaida Esteban-Muñoz, Kilian Tutusaus Pifarré, Francesca Giampieri, Maurizio Battino, Cristina Sánchez‐González, Lorenzo Rivas‐García, Juan Llopis, Tamara Y. Forbes‐Hernández, José L. Quiles
Abstract
model. Our results demonstrated that MH was able to improve indicators of oxidative stress and delayed Aβ-induced paralysis in the AD model CL4176 through HSP-16.2 and SKN-1/NRF2 pathways. Nevertheless, its sugar content impaired the indicators of locomotion (an indicator of tau neurotoxicity) in both the transgenic strain BR5706 and in the wild-type N2 worms.
Topics & Concepts
NeurotoxicityOxidative stressNeuroscienceCaenorhabditis elegansTau proteinIn vivoBiologyGenetically modified mouseAmyloid (mycology)Alzheimer's diseasePharmacologyChemistryBiochemistryTransgeneCell biologyDiseaseToxicityMedicineInternal medicineGeneticsGeneBotanyBee Products Chemical AnalysisGenetics, Aging, and Longevity in Model OrganismsCholinesterase and Neurodegenerative Diseases