Catalytic Enantioselective Synthesis of Spirooxindoles by Oxidative Rearrangement of Indoles
Chenxiao Qian, Pengfei Li, Jianwei Sun
Abstract
Oxidative rearrangement of indoles to access oxindoles has been used as a key step in complex molecule synthesis. We report a catalytic enantioselective variant of this transformation by chiral phosphoric acid catalysis, providing rapid access to a range of enantioenriched spirooxindoles. The high enantioselectivity is controlled by dynamic kinetic resolution.
Topics & Concepts
Enantioselective synthesisCatalysisOxidative phosphorylationCombinatorial chemistryChemistryPhosphoric acidKinetic resolutionOrganic chemistryBiochemistryAsymmetric Synthesis and CatalysisOxidative Organic Chemistry ReactionsAlkaloids: synthesis and pharmacology