Hydroxyl-Rich Hydrophilic Endocytosis-Promoting Peptide with No Positive Charge
Siwen Wang, Zhonghan Li, Desiree Aispuro, Nathan Guevara, Juno Van Valkenburgh, Boxi Chen, Xiaoyun Zhou, Matthew N. McCarroll, Fei Ji, Cong Xu, Priyanka Sarkar, Rohit Chaudhuri, Zhili Guo, Nicole P. Perkins, Shiqun Shao, Jason K. Sello, Kai Chen, Min Xue
Abstract
models. Our study proves that positive charge is not an indispensable feature for hydrophilic cell-penetrating peptides and provides a new category of molecularly well-defined delivery tags for biomedical applications.
Topics & Concepts
EndocytosisTranscytosisChemistryEndosomeCell biologyReceptor-mediated endocytosisPeptideIn vitroCytosolPinocytosisBiophysicsBiochemistryCellBiologyEnzymeRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesPeptidase Inhibition and Analysis