pH stimulus-disaggregated BODIPY: an activated photodynamic/photothermal sensitizer applicable to tumor ablation
Yong‐Chao Liu, Cheng‐Yan Xu, Lili Teng, Hong‐Wen Liu, Tian‐Bing Ren, Shuai Xu, Xiaofeng Lou, Haowei Guo, Lin Yuan, Xiaobing Zhang
Abstract
Herein, we report a pH stimulus-disaggregated BODIPY sensitizer (PTS) with low background-toxicity for achieving activated photodynamic/photothermal tumor therapy. Both the photodynamic and photothermal properties of PTS can be activated under acidic conditions, and PTS exhibits excellent antitumor properties, which is revealed by both in vitro and in vivo tests.
Topics & Concepts
BODIPYTumor ablationPhotothermal therapyPhotochemistryChemistryPhotodynamic therapyStimulus (psychology)AblationMaterials scienceNanotechnologyFluorescenceOrganic chemistryMedicineInternal medicineOpticsPsychologyPsychotherapistPhysicsNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPhotodynamic Therapy Research Studies