Urea Hydrogen Peroxide and Ethyl Lactate, an Eco-Friendly Combo System in the Direct C(sp<sup>2</sup>)–H Bond Selenylation of Imidazo[2,1-<i>b</i>]thiazole and Related Structures
Cassio A. O. Moraes, Rafaely B. C. Santos, Marcos F. O. Cavalcante, Jhefferson S. Guilhermi, Muhammad Ali, Giancarlo V. Botteselle, Tiago Elias Allievi Frizon, Muhammad Ishaq Ali Shah, Luciano M. Lião, Adilson Beatriz, Sumbal Saba, Jamal Rafique
Abstract
High Resolution Image Download MS PowerPoint Slide Herein, we describe a urea hydrogen peroxide-mediated sustainable protocol for the synthesis of selenylated imidazo[2,1- b ]thiazole by using half molar equivalent diorganyl diselenides in ethyl lactate as a greener solvent. The reaction features high yields, easy performance on gram scale, metal-free conditions, as well as applicability to imidazopyridine and imidazopyrimidine.
Topics & Concepts
ThiazoleChemistryHydrogen peroxideUreaEnvironmentally friendlyMolar ratioMedicinal chemistrySolventHydrogen bondCombinatorial chemistryOrganic chemistryCatalysisMoleculeEcologyBiologyOrganoselenium and organotellurium chemistrySulfur-Based Synthesis TechniquesSynthesis and biological activity