Advances in the Understanding of the Pathogenesis of Triple‐Negative Breast Cancer
Yuhan Liu, Yuhan Zou, Yangli Ye, Yong Chen
Abstract
BACKGROUND: Triple-negative breast cancer (TNBC) is a heterogeneous disease characterized by high aggressiveness, high malignancy, and poor prognosis compared to other breast cancer subtypes. OBJECTIVE: This review aims to explore recent advances in understanding TNBC and to provide new insights and potential references for clinical treatment. METHODS: We examined current literature on TNBC to analyze molecular subtypes, genetic mutations, signaling pathways, mechanisms of drug resistance, and emerging therapies. RESULTS: Findings highlight key aspects of TNBC's molecular subtypes, relevant mutations, and pathways, alongside emerging treatments that target drug resistance mechanisms. CONCLUSION: These insights into TNBC pathogenesis may help guide future therapeutic strategies and improve clinical outcomes for patients with TNBC.