USP36-mediated PARP1 deubiquitination in doxorubicin-induced cardiomyopathy
Dongchen Wang, Zihao Jiang, Junyan Kan, Xiaomin Jiang, Pan Chang, Shijie You, Ruirui Chang, Juan Zhang, Hongfeng Yang, Linlin Zhu, Yue Gu
Topics & Concepts
PARP1Gene knockdownDownregulation and upregulationDoxorubicinGene silencingCardiotoxicityCancer researchCell biologyBiologyMolecular biologyApoptosisChemistryPharmacologyPoly ADP ribose polymeraseMedicinePolymeraseBiochemistryInternal medicineEnzymeToxicityChemotherapyGeneGeneticsChemotherapy-induced cardiotoxicity and mitigationPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways