Metformin loaded porous particles with bio-microenvironment responsiveness for promoting tumor immunotherapy
Yuanyuan Wen, Yuxiao Liu, Canwen Chen, Junjie Chi, Liping Zhong, Yongxiang Zhao, Yuanjin Zhao
Abstract
This article presented a novel tumor-microenvironment-responsive particles delivery system with metformin-loaded chitosan inverse opal core and manganese dioxide shell for inhibiting PD-1/PD-L1 signaling pathway and promoting tumor immunotherapy.
Topics & Concepts
ImmunotherapyTumor microenvironmentMetforminChemistryCancer researchManganeseCancer immunotherapyCell biologyTumor cellsImmune systemMedicineImmunologyInternal medicineBiologyInsulinOrganic chemistryNanoplatforms for cancer theranosticsCancer, Stress, Anesthesia, and Immune ResponseImmunotherapy and Immune Responses