The Reovirus σ3 Protein Inhibits NF-κB-Dependent Antiviral Signaling
Andrew J. McNamara, Austin D. Brooks, Pranav Danthi
Abstract
Host cells mount a response to curb virus replication in infected cells and prevent spread of virus to neighboring, as yet uninfected, cells. The NF-κB family of proteins is important for the cell to mediate this response. In this study, we show that a single protein, σ3, produced by mammalian reovirus, impairs the function of NF-κB. We demonstrate that by blocking NF-κB, σ3 diminishes the hosts' response to infection to promote viral replication. This work identifies a second, previously unknown, mechanism by which reovirus blocks this aspect of the host cell response.
Topics & Concepts
BiologyViral replicationVirologyVirusNF-κBCell biologySignal transductionNFKB1GeneticsTranscription factorGeneViral gastroenteritis research and epidemiologyVirus-based gene therapy researchViral Infections and Immunology Research