Tunicamycin Potentiates Antifungal Drug Tolerance via Aneuploidy in Candida albicans
Feng Yang, Vladimir Gritsenko, Yaniv Slor Futterman, Lu Gao, Cheng Zhen, Hui Lu, Yuanying Jiang, Judith Berman
Abstract
Candida albicans is a prevalent human fungal commensal and also a pathogen that causes life-threatening systemic infections. Treatment failures are frequent because few therapeutic antifungal drug classes are available and because drug resistance and tolerance limit drug efficacy.
Topics & Concepts
TunicamycinCaspofunginBiologyAntifungal drugUnfolded protein responseCandida albicansEchinocandinMicrobiologyGeneticsGeneAmphotericin BFluconazoleAntifungalAntifungal resistance and susceptibilityFungal and yeast genetics researchPlant-Microbe Interactions and Immunity