Synthesis and migrastatic activity of cytochalasin analogues lacking a macrocyclic moiety
Bedřich Formánek, Dorian Dupommier, Tereza Volfová, Silvie Rimpelová, Aneta Škarková, Jana Herciková, Daniel Rösel, Jan Brábek, Pavla Perlíková
Abstract
migrastatic activity towards BLM cells but also demonstrated inhibition of actin polymerization, with no cytotoxic effect observed at 50 μM concentration. Our results demonstrate that even compounds lacking the macrocyclic moiety can exhibit biological activities, albeit less pronounced than those of natural cytochalasins. However, our findings emphasize the pivotal role of substituting the core structure in switching between migrastatic activity and cytotoxicity. These findings hold significant promise for further development of easily accessible cytochalasan analogues as novel migrastatic agents.
Topics & Concepts
MoietyCytochalasinChemistryCytochalasin BCytotoxicityCytochalasin DIn vitroStereochemistryBiological activityCytotoxic T cellActinPolymerizationBiochemistryCytoskeletonCellOrganic chemistryPolymerInnovative Microfluidic and Catalytic Techniques InnovationAdvanced Fluorescence Microscopy TechniquesAdvanced Polymer Synthesis and Characterization