Characterization of Proteobacterial Plasmid Integron-Encoded <i>qac</i> Efflux Pump Sequence Diversity and Quaternary Ammonium Compound Antiseptic Selection in Escherichia coli Grown Planktonically and as Biofilms
Carmine J. Slipski, Taylor R. Jamieson-Datzkiw, George G. Zhanel, Denice C. Bay
Abstract
Qac efflux pumps from proteobacterial multidrug-resistant plasmids are integron encoded and confer resistance to quaternary ammonium compound (QAC) antiseptics; however, many are uncharacterized and misannotated. A survey of >2,000 plasmid-carried qac genes identified 37 unique qac sequences that correspond to one of five representative motifs: QacE, QacEΔ1, QacF/L, QacH/I, and QacG.
Topics & Concepts
IntegronEffluxPlasmidMicrobiologyEscherichia coliAntisepticAmmoniumBiologyMultiple drug resistanceBiofilmGeneChemistryBacteriaAntibioticsGeneticsOrganic chemistryAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingBacterial Genetics and Biotechnology