Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity
Dong Huang, Ying-Yuan Zhao, Ruimin Wang, Wei Li, Fang-Yu Yuan, Xue‐Long Yan, Xiao Yang, Gui‐Hua Tang, Sheng Yin, Huichang Bi
Topics & Concepts
Pregnane X receptorCholestasisPharmacologyLiver injuryCYP3A4AgonistNatural productTerpenoidBile acidDownregulation and upregulationChemistryBiologyNuclear receptorBiochemistryReceptorMetabolismEndocrinologyGeneCytochrome P450Transcription factorDrug-Induced Hepatotoxicity and ProtectionDrug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism