Role of inflammatory mediators (TNF-α, IL-6, CRP), biochemical and hematological parameters in type 2 diabetes mellitus patients of Kashmir, India.
Haamid Bashir, Showkat Ahmad Bhat, Sabhiya Majid, Rabia Hamid, Rakesh Koul, Muneeb U. Rehman, Insha Din, Javaıd Ahmad Bhat, Jasiya Qadir, Akbar Masood
Abstract
Low grade inflammation and up regulation of inflammatory mediators has been purported to play a significant role in pathogenesis of T2DM. Our findings confirm that positive correlation of TNF-α and IL-6 with T2DM and insulin sensitivity. These can act as early prediction biomarkers of T2DM. Further studies on wider range of pro and anti- inflammatory cytokines i.e. mediators, in association with other biochemical, immunoassay and hematological parameters are needed to help clinicians manage and treat T2DM effectively.
Topics & Concepts
MedicineType 2 Diabetes MellitusInsulin resistanceInternal medicineDiabetes mellitusGlycemicLipid profileInflammationProinflammatory cytokinePopulationImmunologyInsulinEndocrinologyEnvironmental healthAdipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityLipid metabolism and disorders