Genome-Wide Association Study Identifies Genetic Associations with Perceived Age
Victoria Roberts, Barry Main, Nicholas J. Timpson, Simon Haworth
Abstract
), which were enriched for cell signaling pathways, including the NEK6 and SMAD2 subnetworks. Common genetic variation was estimated to account for 14% of variation in perceived age, and the heritability of perceived age was partially shared with that of 75 other traits, including multiple traits representing adiposity, suggesting that perceived age may be a useful proxy trait in genetic association studies.
Topics & Concepts
HeritabilityBiobankImputation (statistics)Genome-wide association studyGenetic associationGenetic variationHaplotypeTraitBiologyMissing heritability problemGeneticsQuantitative trait locusDemographyGenetic variantsSingle-nucleotide polymorphismGenotypeGeneMissing dataProgramming languageSociologyMachine learningComputer scienceSkin Protection and AgingDermatology and Skin DiseasesGenetic Associations and Epidemiology