Loss of WD2 subdomain of Apaf-1 forms an apoptosome structure which blocks activation of caspase-3 and caspase-9
Ali-Reza Noori, Amin Tashakor, Maryam Nikkhah, Leif A. Eriksson, Saman Hosseinkhani, Howard O. Fearnhead
Topics & Concepts
ApoptosomeCytochrome cCytochromeCaspase-9Binding siteBiologyCaspaseStereochemistryBiophysicsChemistryCell biologyBiochemistryApoptosisProgrammed cell deathEnzymeCell death mechanisms and regulationMitochondrial Function and PathologyATP Synthase and ATPases Research