Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels
Leigh D. Plant, Dazhi Xiong, Jesús G. Romero, Hui Dai, Steven A. Goldstein
Abstract
is confirmed to be SUMO-dependent and to produce action potential prolongation, the pro-arrhythmic change observed in patients.
Topics & Concepts
SUMO proteinHypoxia (environmental)MyocyteSodium channelCell biologyInternal medicineChemistryBiologyPharmacologySodiumMedicineBiochemistryUbiquitinOxygenGeneOrganic chemistryATP Synthase and ATPases ResearchMitochondrial Function and PathologyCardiac electrophysiology and arrhythmias