Emergence of Extensively Drug-Resistant ST170 Citrobacter portucalensis with Plasmids pK218-KPC, pK218-NDM, and pK218-SHV from a Tertiary Hospital, China
Xinhua Luo, Lianhua Yu, Jiao Feng, Jin Zhang, Cheng Zheng, Dakang Hu, Piaopiao Dai, Mengqiao Xu, Piaopiao Li, Ronghai Lin, Kai Mu
Abstract
This is the first report of extensively drug-resistant C. portucalensis harboring both bla KPC-2 and bla NDM-1 . This study will not only extend the understanding of the structural dissection of plasmids and chromosomes carried in C. portucalensis , but also expand knowledge of the genetic environment of the bla KPC-2 and bla NDM-1 genes. bla KPC-2 and bla NDM-1 genes have been suggested to facilitate the propagation and persistence of their host bacteria under different antimicrobial selection pressures.
Topics & Concepts
BiologyWhole genome sequencingPlasmidResistomeMobile genetic elementsDrug resistanceGeneticsCitrobacterPhylogenetic treeGeneGenomeMicrobiologyEnterobacteriaceaeEscherichia coliAntibiotic Resistance in BacteriaInfections and bacterial resistanceVibrio bacteria research studies