BRAF + EGFR +/- MEK inhibitors after immune checkpoint inhibitors in BRAF V600E mutated and deficient mismatch repair or microsatellite instability high metastatic colorectal cancer
Margherita Ambrosini, David Tougeron, Dominik Paul Modest, Rosine Guimbaud, Scott Kopetz, Marie Decraecker, Stéfano Kim, Clélia Coutzac, Géraldine Perkins, Emily Alouani, Federica Marmorino, Simon Pernot, Frank A. Sinicrope, Elena Élez, Pauline Parent, Chiara Cremolini, Filippo Pietrantonio, Sara Lonardi, Claire Gallois, Julien Taı̈eb
Topics & Concepts
Microsatellite instabilityColorectal cancerCancer researchDNA mismatch repairMedicineV600EMEK inhibitorEGFR inhibitorsMutationImmune checkpointOncologyCancerInternal medicineImmunotherapyBiologyMAPK/ERK pathwayEpidermal growth factor receptorGeneticsPhosphorylationMicrosatelliteGeneAlleleGenetic factors in colorectal cancerColorectal Cancer Treatments and StudiesLung Cancer Treatments and Mutations