Sortase A Inhibitor Protein Nanoparticle Formulations Demonstrate Antibacterial Synergy When Combined with Antimicrobial Peptides
Sitah Alharthi, Amirali Popat, Zyta M. Ziora, Peter M. Moyle
Abstract
: 25.0-81.8 µg/mL), and did not affect HEK-293 cell viability at their MIC or optimal synergistic concentrations with AMPs. Overall, this study provides a safe nanoplatform for enhancing antimicrobial synergy to develop treatments for superbug infections.
Topics & Concepts
Sortase AAntimicrobialAntimicrobial peptidesMicrobiologyMinimum inhibitory concentrationBacteriaViability assayChemistrySortaseStaphylococcus aureusBiochemistryBiologyCellGeneticsBiochemical and Structural CharacterizationBotanical Research and ChemistryBotulinum Toxin and Related Neurological Disorders