Interleukin-6 promotes microtubule stability in axons via Stat3 protein–protein interactions
Lauren K. Wareham, Franklin D. Echevarría, Jennifer L. Sousa, Danielle O. Konlian, Gabrielle Dallas, Cathryn R. Formichella, Priya Sankaran, Peter J. Goralski, Jenna R. Gustafson, Rebecca M. Sappington
Abstract
studies in mice and swine revealed that IL-6-dependent microtubule phenotypes arise from protein-protein interactions between STAT3 and stathmin. As in tumor cells and T cells, this STAT3-stathmin interaction stabilizes microtubules in RGCs. Thus, this IL-6-STAT3-dependent mechanism for axon architecture is likely a fundamental mechanism for microtubule stability systemically.
Topics & Concepts
MicrotubuleCell biologyAxonSTAT3BiologyNeuroscienceSignal transductionAxon Guidance and Neuronal SignalingCytokine Signaling Pathways and InteractionsNeurogenesis and neuroplasticity mechanisms