Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis
Wei Zhou, Heng Liu, Zhe Yuan, Joseph A. Zundell, Martina Towers, Jianhuang Lin, Simona Lombardi, Hao Nie, Brennah Murphy, Tyler T. Yang, Chen Wang, Liping Liao, Aaron R. Goldman, Toshitha Kannan, Andrew V. Kossenkov, Ronny Drapkin, Luis J. Montaner, Daniel T. Claiborne, Nan Zhang, Shuai Wu, Rugang Zhang
Topics & Concepts
ARID1AMevalonate pathwayCancer researchBiologyPyroptosisMutationReductaseEnzymeApoptosisProgrammed cell deathBiochemistryGeneCancer Mechanisms and Therapyinterferon and immune responsesChromatin Remodeling and Cancer