Simultaneous quantification of donafenib, sorafenib, and their N-oxide metabolites in rat plasma using a HPLC-MS/MS method
Yutao Lou, Zhiyong Sun, Yitao Chai, Hui Qin, Qing Hu, Yujia Liu, Xiaowei Zheng, Ying Hu, Meihua Bao, Jinping Gu, Yiwen Zhang
Topics & Concepts
ChemistryChromatographySorafenibProtein precipitationPharmacokineticsBioanalysisAnalyteHigh-performance liquid chromatographySelected reaction monitoringTandem mass spectrometryMetaboliteMass spectrometryPharmacologyHepatocellular carcinomaBiochemistryBiologyMedicineCancer researchHepatocellular Carcinoma Treatment and PrognosisPharmacogenetics and Drug MetabolismCancer Treatment and Pharmacology