Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus <i>In Vitro</i>
Jickky Palmae Sarathy, Matthew Zimmerman, Martin Gengenbacher, Véronique Dartois, Thomas Dick
Abstract
, suggesting target retention. OPC-167832 was bactericidal and did not antagonize activity of clinical anti-M. abscessus antibiotics. Due to its moderate potency compared to that against Mycobacterium tuberculosis, the compound lacked efficacy in a mouse model and is thus not a repurposing candidate. These results identify OPC-167832-DprE1 as a lead-target couple for a M. abscessus-specific optimization program.
Topics & Concepts
Mycobacterium abscessusMycobacterium tuberculosisMicrobiologyPotencyTuberculosisAntibioticsRepurposingMycobacteriumIn vitroMedicineBiologyImmunologyPathologyEcologyBiochemistryMycobacterium research and diagnosisTuberculosis Research and EpidemiologyInfectious Diseases and Mycology