Construction of <i>N</i>-Polyheterocycles by <i>N</i>-Heterocyclic Carbene Catalysis via a Regioselective Intramolecular Radical Addition/Cyclization Cascade
Qijing Zhang, Hao Lei, Cong‐Ying Zhou, Chengming Wang
Abstract
-heterocyclic carbene (NHC) catalysis through regioselective sequential radical addition/cyclization in the absence of any metals or oxidants. The transformation occurs under mild conditions and enjoys a wide substrate scope with excellent functional group compatibility. Furthermore, a gram-scale synthesis is also conducted. Preliminary mechanistic studies reveal the potential involvement of an NHC radical cation intermediate.
Topics & Concepts
ChemistryRegioselectivityCarbeneIntramolecular forceCatalysisCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods