MicroRNA let-7i Inhibits Histone Lysine Demethylase KDM5B to Halt Esophageal Cancer Progression
Yang Yang, Wenhua Li, Bochong Wei, Kai Wu, Donglei Liu, Dengyan Zhu, Chun‐yang Zhang, Fengbiao Wen, Yuxia Fan, Song Zhao
Abstract
. Taken together, our findings reveal the tumor-suppressive properties of let-7i in esophageal cancer in association with an apparent KDM5B-dependent SOX17/GREB1 axis. This study offers a potential prognostic marker and therapeutic target for esophageal cancer.
Topics & Concepts
H3K4me3DemethylasemicroRNAEsophageal cancerCancer researchCancerSuppressorCancer cellIn vivoIn vitroHistoneBiologyPromoterMedicineInternal medicineGene expressionGeneGeneticsMicroRNA in disease regulationEpigenetics and DNA MethylationRNA modifications and cancer