Ball-milling and piezoelectric materials enabled radical trifluoromethylation of enamides and acrylamides
Vitalii Solomin, Matthias Liard, Philippe Jubault, Thomas Castanheiro
Abstract
A sustainable solid-state direct radical C(sp 2 )–H trifluoromethylation of enamide derivatives was developed by merging ball-milling with a stoichiometric amount of piezoelectric materials. Acrylamide were suitable substrates in this transformation.
Topics & Concepts
TrifluoromethylationChemistryBall millPiezoelectricityOrganic chemistryChemical engineeringComposite materialEngineeringMaterials scienceAlkylTrifluoromethylFluorine in Organic Chemistry