Spotlight on alternative frame coding: Two long overlapping genes in Pseudomonas aeruginosa are translated and under purifying selection
Michaela Kreitmeier, Zachary Ardern, Miriam Abele, Christina Ludwig, Siegfried Scherer, Klaus Neuhaus
Abstract
, are the longest yet proposed in prokaryotes and are among the best attested in terms of translation and evolutionary constraint. These results highlight a potentially large unexplored dimension of prokaryotic genomes.
Topics & Concepts
ORFSBiologyNegative selectionOpen reading frameGeneGenomeComputational biologyGeneticsProteomeRibosome profilingProteomicsRibosomeRNAPeptide sequenceGenomics and Phylogenetic StudiesRNA and protein synthesis mechanismsBacterial Genetics and Biotechnology