Skeletal muscle transcriptome response to a bout of endurance exercise in physically active and sedentary older adults
Aliza B. Rubenstein, J. Matthew Hinkley, Venugopalan D. Nair, German Nudelman, Robert A. Standley, Fanchao Yi, Gongxin Yu, Todd A. Trappe, Marcas M. Bamman, Scott Trappe, Lauren M. Sparks, Bret H. Goodpaster, Rick B. Vega, Stuart C. Sealfon, Elena Zaslavsky, Paul M. Coen
Abstract
Muscle transcript signatures associated with oxidative capacity and immune cells underlie important phenotypic and clinical characteristics of older adults who are endurance trained or sedentary. Despite divergent phenotypes, the temporal transcriptional signatures in response to an acute bout of endurance exercise were largely similar among groups. These data provide new insight into the transcriptional programs of aging muscle and the beneficial effects of endurance exercise to promote healthy aging in older adults.