Pd-Catalyzed Enantioselective Dicarbofunctionalization of Alkene to Access Disubstituted Dihydroisoquinolinone
Qiaoyu Chen, Sanliang Li, Xiaoxiao Xie, Hao Guo, Junfeng Yang, Junliang Zhang
Abstract
A Pd/Xu-Phos-catalyzed asymmetric Heck/Suzuki domino reaction has been developed that shows high functional group tolerance and enables coupling with various aryl/alkenyl borates. A series of chiral disubstituted dihydroisoquinolinones could be obtained in good yields and excellent enantioselectivities.
Topics & Concepts
ChemistryEnantioselective synthesisAlkeneDominoArylCatalysisFunctional groupSuzuki reactionCombinatorial chemistryBoronHeck reactionMedicinal chemistryPalladiumOrganic chemistryAlkylPolymerAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis