Pd‐Catalyzed Directed Thiocyanation Reaction by C−H Bond Activation
Mélissa Gao, Mu‐Yi Chen, Xavier Pannecoucke, Philippe Jubault, Tatiana Besset
Abstract
The Pd-catalyzed directed thiocyanation reaction of arenes and heteroarenes by C-H bond activation was achieved. In the presence of an electrophilic SCN source, this original methodology offered an efficient tool to access a panel of functionalized thiocyanated compounds (21 examples, up to 78 % yield). Post-functionalization reactions further demonstrated the synthetic utility of the approach by converting the SCN-containing molecules into value-added scaffolds.
Topics & Concepts
ElectrophileCatalysisYield (engineering)ChemistrySurface modificationCombinatorial chemistryReaction conditionsOrganic chemistryMaterials scienceMetallurgyPhysical chemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions