A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy
Greta Giordano-Attianese, Pablo Gaínza, Elise Gray-Gaillard, Elisabetta Cribioli, Sailan Shui, Seonghoon Kim, Mi‐Jeong Kwak, Sabrina S. Vollers, Angel De Jesus Corria Osorio, Patrick Reichenbach, Jaume Bonet, Byung‐Ha Oh, Melita Irving, George Coukos, Bruno E. Correia
Topics & Concepts
Chimeric antigen receptorCD28AntigenT-cell receptorSmall moleculeIn vitroCell biologyT cellIn vivoReceptorChemistryBiologyComputational biologyMolecular biologyBiochemistryCytotoxic T cellImmunologyGeneticsImmune systemCAR-T cell therapy researchNanowire Synthesis and ApplicationsAdvancements in Semiconductor Devices and Circuit Design