Advancements in polycaprolactone nanoparticles for targeted drug delivery in breast cancer treatment: Strategies and challenges
Kalakar Sahu, Komal Naeem, Miriya R. Carson, Nabira Kanwal Nawaz, Naila Gulfam, Muhammad Zahoor
Abstract
Poly(ε-caprolactone; PCL) is a biodegradable and biocompatible polyester that can be suitable to develop nanoparticles for sustainable drug delivery applications and improve the efficacy of Breast cancer treatment. In this review, we summarize some latest advances in targeted delivery strategies Such as Active Targeting, Passive Targeting and Stimuli Responsive targeting for PCL-based drug carriers and explore their potential applications in delivering key anticancer agents used for effective Breast cancer therapy. We were intendent to analyse the effectiveness as well as limitations of different types of targeting delivery strategies for PCL-based drug carriers and the effectiveness of these approaches in improving drug bioavailability, reducing side effects, and achieving sustained release. By analysing current trends and narrowing knowledge gaps, this work provides insights into optimizing PCL-based systems to improve therapeutic efficacy and paves the way for innovative applications in Breast cancer treatment.