Synthesis, Structure Characterization, and Antioxidant and Antibacterial Activity Study of Iso-orientin–Zinc Complex
Xiao Wang, Shenyuan He, Yuan Li, Hong Deng, Zhong Zhang
Abstract
Flavonoid–metal complexes possess more effective functional properties than flavonoids. However, the research of iso-orientin (Iso)–metal complex has rarely been reported. In this study, Iso–zinc complex (Iso–Zn, [Zn3(C21H14O11)2]·4H2O) had been synthesized and characterized. From the UV–vis spectra and IR spectra, the 4-carbonyl group in the C-ring of Iso was involved in the metal chelation besides A-ring and B-ring hydroxyl group. Thermal gravimetric analysis and the water contact angle test showed that Iso–Zn had higher thermal stability and better hydrophilicity than Iso, respectively. The radical scavenger and antibacterial potencies of Iso–Zn were significantly stronger than those of Iso. Furthermore, Iso–Zn showed lower erythrocytes hemolysis ratio and cytotoxicity. The present study demonstrated that Iso–Zn exhibited better water solubility, antioxidative and antibacterial activities, and lower cytotoxicity and provided a theoretical basis for expanding the utilization scope of Iso through enhancing its hydrophilicity.