Zinc salt-catalyzed reduction of α-aryl imino esters, diketones and phenylacetylenes with water as hydrogen source
Guoli Shen, Haojie Liu, Jingchao Chen, Zhenxiu He, Yongyun Zhou, Lin Wang, Luo Yang, Zhimin Su, Baomin Fan
Abstract
The zinc salt-catalyzed reduction of α-aryl imino esters, diketones and phenylacetylenes with water as hydrogen source and zinc as reductant was successfully conducted. The presented method provides a low-cost, environmentally friendly and practical preparation of α-aryl amino esters, α-hydroxyketones and phenylethylenes. By using D2O as deuterium source, the corresponding products were obtained in high efficiency with excellent deuterium incorporation rate, which gives a cheap and safe tool for access to valuable deuterium-labelled compounds.
Topics & Concepts
ChemistryZincCatalysisArylSalt (chemistry)Medicinal chemistryHydrogenOrganic chemistryCombinatorial chemistryAlkylAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisNanomaterials for catalytic reactions