Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice
Zunji Shi, Hehua Lei, Gui Chen, Peihong Yuan, Zheng Cao, Hooi‐Leng Ser, Xuehang Zhu, Fang Wu, Caixiang Liu, Manyuan Dong, Yuchen Song, Yangyang Guo, Chuan Chen, Kexin Hu, Yifan Zhu, Xin-an Zeng, Jinlin Zhou, Yu‐Jing Lu, Andrew D. Patterson, Limin Zhang
Abstract
Our findings indicate that the gut-liver signaling axis contributes to saccharin/sucralose consumption-induced NAFLD. Supplementation with metformin or fructo-oligosaccharide is a potential therapeutic strategy for NAFLD treatment. In addition, we also developed a new nutritional strategy by using a natural sweetener (neohesperidin dihydrochalcone [NHDC]) as a substitute for NAS and free sugars.
Topics & Concepts
Akkermansia muciniphilaMetforminSucraloseNonalcoholic fatty liver diseaseAryl hydrocarbon receptorAMPKSaccharinChemistrySteatosisFatty liverInternal medicineMedicineDiabetes mellitusBiochemistryEndocrinologyFood scienceDiseaseGut floraGeneProtein kinase ATranscription factorEnzymeBiochemical Analysis and Sensing TechniquesDiet, Metabolism, and DiseaseLiver Disease Diagnosis and Treatment