T cells in pancreatic cancer stroma
Michelle R. Goulart, Konstantinos Stasinos, Rachel Elizabeth Ann Fincham, Francesca Romana Delvecchio, Hemant M. Kocher
Abstract
cytotoxic lymphocytes that are localised along the invasive margin of the tumour border in the surrounding fibrotic tissue, and often display an exhausted phenotype. Here, we review the role of T cells in pancreatic cancer, examine the complex interactions of these crucial effector units within pancreatic cancer stroma and shed light on the increasingly attractive use of T cells as therapy.
Topics & Concepts
StromaPancreatic cancerStromal cellTumor microenvironmentImmune systemCytotoxic T cellCancer researchBiologyInfiltration (HVAC)CD8Cancer cellPathologyCancerImmunologyMedicineImmunohistochemistryIn vitroPhysicsBiochemistryThermodynamicsGeneticsPancreatic and Hepatic Oncology ResearchCancer Immunotherapy and BiomarkersImmune cells in cancer