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Chromothripsis drives the evolution of gene amplification in cancer

Ofer Shoshani, Simon Brunner, Rona Yaeger, Peter Ly, Yael Nechemia‐Arbely, Dong Hyun Kim, Rongxin Fang, Guillaume A. Castillon, Miao Yu, Julia S. Z. Li, Ying Sun, Mark H. Ellisman, Bing Ren, Peter J. Campbell, Don W. Cleveland

2020Nature474 citationsDOIOpen Access PDF

Topics & Concepts

ChromothripsisBiologyExtrachromosomal DNAGene duplicationGeneticsGenome instabilityGeneChromoplexyDNACancerMolecular biologyGenomeCancer researchDNA damageProstatePCA3Cancer Genomics and DiagnosticsCRISPR and Genetic EngineeringDNA Repair Mechanisms
Chromothripsis drives the evolution of gene amplification in cancer | Litcius