Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease
Nikita Ollen‐Bittle, Shervin Pejhan, Stephen Pasternak, C. Dirk Keene, Qi Zhang, Shawn N. Whitehead
Topics & Concepts
Mass spectrometry imagingPathologyEntorhinal cortexAlzheimer's diseaseMALDI imagingChemistrySphingolipidGangliosideHuman brainNeuroscienceBiologyDiseaseHippocampusMedicineBiochemistryMass spectrometryMatrix-assisted laser desorption/ionizationDesorptionChromatographyOrganic chemistryAdsorptionMetabolomics and Mass Spectrometry StudiesDiet and metabolism studiesAlzheimer's disease research and treatments