Isolation and characterization of novel acetylcholinesterase inhibitors from <i>Ficus benghalensis</i> L. leaves
Heba Ali Hassan, Ahmed E. Allam, Dalia H. Abu‐Baih, Mamdouh F. A. Mohamed, Usama Ramadan Abdelmohsen, Kuniyoshi Shimizu, Samar Yehia Desoukey, Alaa M. Hayallah, Mahmoud A. Elrehany, Khaled M. Mohamed, Mohamed Kamel
Abstract
comparison to other literature. Studies on the acetylcholinesterase inhibition potential and antioxidant activity were carried out on the total methanolic leaf extract, ethyl acetate fraction, and the isolated compounds. The results revealed the potent acetylcholinesterase inhibition of mucusoside alongside a new compound. Docking studies were also performed to confirm the possible interaction between the isolated compounds and acetylcholinesterase accompanying Alzheimer's disease progress.
Topics & Concepts
Ethyl acetateAcetylcholinesteraseChemistryPhytochemicalStereochemistryAntioxidantTraditional medicineOrganic chemistryBiochemistryEnzymeMedicinePhytochemistry and biological activities of Ficus speciesPhytochemistry and Biological ActivitiesPhytochemistry and Bioactivity Studies