Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer
Huhu Zhang, Zhe Zhang, Tingting Guo, Guang Chen, Guoxiang Liu, Qinghang Song, Guichun Li, Fenghua Xu, Xiaolei Dong, Fanghao Yang, Can Cao, Di Zhong, Shuang Li, Ya Li, Mengjun Wang, Bing Li, Lina Yang
Abstract
phospholipid-binding proteins. A considerable amount of literature is available on the abnormal expression of ANXA proteins in various malignant diseases, including cancer, atherosclerosis and diabetes. As critical regulatory molecules in cancer, ANXA proteins play an essential role in cancer progression, proliferation, invasion and metastasis. Recent studies about their structure, biological properties and functions in different types of cancers are briefly summarised in this review. We further discuss the use of ANXA as new class of targets in the clinical diagnosis and treatment of cancer.